Publications
Selected landmark and recent work
Explore landmark and current work spanning p53 DNA recognition, transcriptional context, MDM2 and MDMX regulation, mutant gain of function, tumour invasion, metabolism and therapeutic vulnerability.
Genes & Development
Mutant p53: evolving perspectives
Proceedings of the National Academy of Sciences
Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway-dependent Rho/ROCK signaling
Cancer Discovery
Mutant p53 Gain of Function: Why Many See It, Why Some Do Not
Molecular Cell
A fork in the road: PADI4 citrullinates p53 to control immune-related networks
Cell
p53: A tale of complexity and context
Molecular Cancer Research
Systematic Characterization of p53-Regulated Long Noncoding RNAs across Human Cancers Reveals Remarkable Heterogeneity among Different Tumor Types
Cancer Discovery
Li-Fraumeni Syndrome-Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Cell
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Genes & Development
Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers
Genes & Development
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells
Molecular and Cellular Biology
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain
Science